Gamma Delta T Cells

20130516-111029.jpgGamma Delta T cells are one of the most potent of all the Leukocytes, but they only make up a very small percentage of the white blood cell population. Gamma Delta cells are much more primitive than other white cells, and as a result, are not regulated by T-Reg cells. This is important because T-Reg cells potentiate immune reactions and are believed to play a role in cancer’s ability to thwart the immune system. Gamma Delta T cells are mavericks and this is why they have so much potential as cancer fighters…. when primed. GD T Cells are part of the more primitive innate immune system.

Today I start the first step of Gamma Delta T Cell therapy and will receive Zometa IV for the next two days. Zometa is a drug typically used to treat bone mets. One of its side effects however, is to stimulate Gamma Delta T cells, causing them to multiply.

Two days after Zometa has done its work, a dendritic cell vaccine is administered. The dendritic cells should activate the greatly increased Gamma Delta T cell population, and the battle will begin.

As with most immunotherapies, this treatment also has limited period of efficacy. With repeat use, over time, Zometa will become ineffective.

An alternate version of this therapy is to harvest Gamma Delta cells from a healthy donor. The cells are then cultured in the lab, primed and administered. It is not known which procedure is more effective, as it is all very much experimental, but while I am in Germany, I may as well try both.

The donors for this treatment are usually nurses working at the Duderstadt clinic. There is this healthy looking nurse, well built too, that I have my eye on. Hope its her cells that I get. 🙂 This could be an interesting pick up line. “You look pretty healthy, can I buy you a drink and have your blood?”

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About Ren

I have been diagnosed with stage 4, metastatic colorectal cancer in October 2012, 3 days after my 44th birthday. There is no cure, but I am determined to go down the road less travelled to find one. I have setup this blog to document my journey and hopefully help others in the process. My view is that if there is a cure, it does not lie with traditional chemo, but with the immune system. Time will tell.
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2 Responses to Gamma Delta T Cells

  1. Rona0909 says:

    I think what’s tragic is your comment that most immunotherapies will become ineffective over time. Does this apply to Removab as well? It seems to me that cancer is a canny beast and seems to find ways to outwit most treatments and even if NED is achieved, there’s no guarantee the cancer won’t come back. How are you monitoring the success of the treatments? Is it through tumour markers, PET scans, CTCs?

  2. Ren says:

    Yes, the same applies to Removab, it too becomes less effective the more times you use it.
    As far as tracking progress, the next MRI will tell all. As far as cancer markers, CEA is still climbing., however CA19-9 is down but still in the 100k range.

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