PNAE (plasmanyl-N-acyl-etanolamine or 1-0-alkyl-2-acyl-sn-glycero-3-phospho-(N-acyl) ethanolamine) is another potential supplement which may aid in the fight agains solid tumour cancers like adenocarcinoma.
PNAE activity is based on the differences in metabolism of ether phospholipids in healthy and cancerous cells. Healthy cells carry the enzyme alkylglycerolmonooxygenase that cleaves the PNAE molecule. The resulting fragments are used for biosynthesis of lipids and phospholipids. These form an essential part of the cell membranes. This enzyme is absent or inactive in tumour cells. This leads to the accumulation of PNAE inside the tumour cells causing their destruction while healthy cells remain undamaged.
PNAE’s second method of action is the inhibitory effect on the protein kinase C (PKC). This protein appears in tumour cells in elevated concentration. PKC affects enzymes that play an important role in regulating cell proliferation. Its method of action is thus similar to tamoxifen, adriamicin and calphostin, but without the toxic side effects.
In addition, PNAE has been shown that it can also stimulate the immune system.
PNAE was developed and is produced in the Czech Republic. It is marketed as a supplement under the brand OVOSAN. Its available in most pharmacies there. There is also a russian distributor which delivers world wide I believe.
PNAE is extracted from egg yolks.
I started taking a high dose of the phospholipid PNAE this week. 3 capsules 3 time a day, morning, noon and night. At roughly $900 for a two month supply, its not a cheap supplement however.